Warnings and precautions: 

• All administration operations must be performed gently, avoiding inserting the tip of the dispenser too deeply into the nostrils and maintaining an upright position during use. 
• Close the bottle tightly after each application. 
• Store the product away from light and direct heat sources. 
• If persistent or severe side effects occur, discontinue use and consult a physician or pharmacist. 
• For children, use should be supervised by an adult. 

Contraindications: 

• Hypersensitivity (allergy) to any component of the product. 
• Use in individuals with untreated viral or bacterial infections of the upper respiratory tract. 
• Use in children below the recommended age or in conditions requiring specific medical evaluation.

HYPERNASE is a hypertonic solution buffered at 3% sodium chloride and 0.1% hyaluronic acid, indicated for nasal mucosa decongestion and mucus thinning in cases of colds and other rhinopathies characterized by typical symptoms: 

• Nasal congestion; 
• Clear nasal discharge, yellow-green or white; 
• Sneezing. 

The HYPERNASE solution for aerosol therapy can be used to dilute medications intended for rhinological treatments; in this case, follow strictly the instructions on the medication packaging or those provided by your physician.

15 ml nasal sprays 

Children: HYPERNASE Nasal Spray Children (3–12 years) 
Adults: HYPERNASE Nasal Spray Adult (>12 years) 

Solution for aerosol therapy 3-5 ml/dose 

Adults and Children: HYPERNASE Nebules Children (>3 years) 

Functional substances: 

Sodium chloride 3%, Sodium hyaluronate 350–1150 KDa at 0.1% (sodium salt of hyaluronic acid). 

Excipients: 

Purified water FU, Mint flavoring, Eucalyptol, Methylparaben, Propylparaben, Monosodium phosphate dihydrate (or Citric Acid monohydrate), Disodium phosphate dodecahydrate (or Sodium Citrate dihydrate).

Decongests the nasal mucosa and thins mucus present in nasal cavities.  

The hypertonic solution at 3% sodium chloride exerts an osmotic effect on the surface of the nasal mucosa that thins mucus and promotes fluid drainage from swelling caused by excess fluid accumulation.  

High molecular weight hyaluronic acid provides a protective barrier effect on the nasal mucosa and supports restoration of mucociliary clearance. 

Nasal Sprays: 

Children (3–12 years): 1–2 sprays per nostril several times daily (usually 3–4), until symptoms improve or as advised by a doctor. 

Adults (>12 years): 2–3 sprays per nostril several times daily (usually 3–4), until symptoms improve or as advised by a physician.  

Aerosol Therapy: 

Adults and children (>3 years): nebulize 3 or 5 ml of solution into both nostrils using a micronized nasal shower, two or three times a day, until the symptoms disappear, or as advised by a physician. 

Note:  

The duration of treatment can be adjusted based on clinical response; however, minimum duration is five days: shorter treatments do not guarantee effectiveness.

For nasal spray (children and adults): 

1. Blow your nose to remove mucus or residues to allow the product to reach nasal areas. 
2. Remove the dispenser safety and protective cap. 
3. Prime the pump by pressing 2–3 times until a steady spray is obtained. 
4. Gently insert the dispenser tip into one nostril, keeping your head upright and slightly tilted forward. 
5. Spray once while inhaling slowly through your nose. 
6. Repeat in the other nostril following the same procedure. 

For aerosol therapy (children and adults): 

1. Blow your nose to remove mucus or residues to allow the product to reach nasal areas. 
2. Ensure bottle is intact and properly sealed before opening. 
3. Open by turning counterclockwise then break tamper-proof seal. 
4. Draw up 3 or 5 ml using supplied syringe. 
5. Insert liquid into micronized nasal shower as per nebulizer device instructions. 
6. Nebulize into both nostrils until all liquid is used up in the ampoule of the micronized nasal shower. 

Note:  

Do not exhale or blow your nose immediately after application to avoid dispersing the product (wait 10-15 minutes). Use in children must be supervised or assisted by an adult.

• Hypersensitivity (allergy) to any component of HYPERNASE. 
• Use in individuals with untreated viral or bacterial infections of upper respiratory tracts. 
• Use in children below age recommendations or conditions requiring medical evaluation.

It may cause: 

• A burning sensation immediately after application. 

Rare adverse effects include: 

• Irritation of the throat and palate; 
• Sneezing and watery eyes; 
• Small blood losses (epistaxis), especially in cases of nasal vascular fragility; 

If persistent or severe side effects occur, discontinue use and consult a physician or pharmacist. 

All operations should be performed gently: avoid inserting the tip of the dispenser too deeply into the nostrils; maintain an upright position during application. 

After each administration: 

• Close bottle tightly; 
• Keep away from direct light; 
• Store out of reach of children. 

Specific warnings: 

• Aerosol solution must be administered exclusively through a micronized nasal shower —not via masks or oral nebulizers designed for lower airways! 
• Do not use after expiration date printed on packaging! 
• HYPERNASE solution is not sterile nor injectable! 
• Keep out of reach of children! 
• Do not use if bottle is damaged or not properly sealed! 

You can receive real-time support on how to use HYPERNASE by scanning the QR code below:  

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Online assistance is provided by Nevia Biotech’s artificial intelligence system, monitored by a human supervisor who is an expert on the product and will intervene within 24 hours if necessary.

Store at a temperature between +10°C and +30°C, away from direct light and heat sources; keep out of reach of children; do not use beyond twomonths after opening or after the expiration date indicated on the packaging.

Last revision: June/2025 

Version: 2.0